They need to find a way to detect XIV Alexander and ban people

[Naizakane]

They could use nProtect GameGuard like PSO2, if it detects any 3rd party program running that the game devs dont like it gives you Error 1013 and force you to close the game, crashes the game or gives BSOD. If that's not enough, implement checksum file that the game checks and updates regularly while you're online.
In PSO2 if the devs find people using parser they ban accounts without warning for cheating.

I guess the anti parser people would be happy.

I can't quite give you a short summary of how funny this is to anyone who knows about OverParse.

Okay great. But if it's random, any tool would be unable to predict it. You know why? Because they get their info from the server at the same time your client does. There is literally nothing any tool could do to somehow read the future.

In E4S, Cactbot would tell you the safespots for the left/right punches, which were random and only communicated via an animation, before the animation tell.