Not really. The easiest job is similar to champions in LoL : one model, clothing integrated as a direct shape of the character. As soon as you do clothes, since you have two genders, you have two basic bodyshapes, it far easier and faster to extract one clothing from each and develop it specifically rather than doing one for both and copy one to another. Just the copy can generate ghost clipping. This because of topology and shape keys (especially since you need to delete as many hidden part as possible to avoid clipping and useless GPU work).
The more HD is topology, the farest topologies are between genders (hips and breast for example).