Now on this list I am going to go into detail of the best combo of lost actions that I have experienced with 17 relics and R25 with full 10 honor on health, damage, heals. Reminder that this is my opinion in which you are welcome to disagree.
(Reminder that the Essences mentioned are primarily for open areas, not raids as there are better buffs for those)
Healers
Seraph Strike+Burst+Any DPS Buff Over 60%:
With Seraph Strike, you get a flat dps bonus for a short time that truly noone cannot see to be a benefit for dps as a healer. Yet many tend to neglect Lost Burst. It has 3 key benefits.
1. It does almost equal amounts of damage per cast as a aoe to every mob it hits at 300 potency like Flare Star.
2. It applies a static magic debuff on all mechanical mobs of 5-10% which 60-70% of mobs in Bojza are this classification(I havent looked for the exact %, could be more)
3. It cost no mana to use except it does require refilling at cap of 99 uses. This is easily overcome from the mobs farmed right in front of camp in Zadnor or certain mobs in zone 1.
All these reasons above including the static damage buffs you will get from using this with make you do on average 30-50k per aoe mob hit depending on total dps buffs/debuffs.
Physical DPS(Both Melee/Ranged)
Beast+Assassination+Player Choice(My Preference being Spellforge since as already mentioned 60-70% of mobs are mechanical weak to magic):
Beast gives you a static defense and hp regen per hit and with assassination you get for 18 secs a static 40% bonus to dps. With spellforge in my opinion you only add to that against bot mobs.
BLM
Savior+Lost Flare Star+Any Cure Lost Action:
We all know that Lost Flare Star does crazy damage equal to 300 potency on cast as a aoe and every mob 350 potency per tick.(Many may say that both RDM and Sum can use it as well but nowhere near consistently as a BLM who has unlimited mana regen with Umbral Soul unless they pop ethers like every 1 min)
Now your initial reaction may be "uggh, Essence of the Savior?", why? Because it almost makes you immortal to continue dotting with Flare Star. Now you can sub this for Skirmisher for a extra 20% but in my opinion nowhere comps for the 50-70k static heal and 15k-20k per tick regen you get in return.
RDM/SUM
Ordained+Chain Spell+Lost Death
Ordained should be a giving to anyone who is familiar with its 20% dps buff, increased heals and mana.
Chain Spell gives you a 100% dps increase for 30 secs while removing the additional mana costs from normally associated with it. This when paired for example on the SUM rotation during the Bahamut summon phase with hard casting Ruin will only amplify the damage done and also make it instant cast similar to the prior phase to make SUM not have hardly any hard cast spell to contend with.
Lost Death...you one shot most mobs, with ordained its even a higher chance to succeed. Enough said!
Tanks
Lost Rampage+Lost Font of Power+Any DPS Buff:
Lost Rampage similar to Burst will add a debuff to any mobs prone to physical damage as a aoe doing average 15k to 30k depending on buffs to all mobs.
Lost Font of Power paired with Rampage not only amplifies your damage for it, but it also increases even more with Irregular on if you decide to use that Essence to another 40% for 30 secs. Now imagine that 30 sec window with Rampage as a aoe being buffed with Font of Power. My maximum at this writing consistantly was 30-40k per mob hit. This comes in handy if you are tanking to grab aggro from a group of mobs and also debuff them at the same time if they are weak to physical.
I hope everyone found this information useful and as I mentioned, you could disagree and would love to hear potentially why and maybe some combos you use that shines.
See everyone in Bojza and Endwalker!