Got a possible fix.

I tried everything:
1) I'm fully OS patched.
2) My devices have no new drivers.
3) Did the IE reset
4) Rebooted the modem
5) Run as admin

Nothing was working...

What did work, and thanks to FFXIV Reddit here, was move to the "old" layout. No idea why, but it works.

Looks like they may of introduced a bug into the data the new layout receives. Given the old still works.