How is it that no one throws a "brand" in there? I have a half ghetto setup with a few 50~'s, and with HQ mats I get rediculous success with: Comfort Zone for 1 standard and 2 careful's (negates that extra loss from standard (since patch) and gives you two free not-awesome carefuls), then By the Book (or w/e if you have it) and you start at 50% done, around 10% (or more) HQ, and 100% durability.
After that Byregot's 3x and Inspiration 3x leaves you around 38-42 Durability (lowball'd) and around 70% HQ. Since careful's run about 8~ dura loss, you can finish out on that easily, and in a worst case scenario another standard if you need it. The only thing that'll break you is unstable. I could use 4 abil's and HQ all day, but the "Brand of Wind" or whatever ele.. Nets me a free 100 quality and complete stability if my synth happens to freak out. Way way more useful than people are letting one especially at 50+ synths.