I like stacking Byregot's Blessing and one the two 125% Quality-on-next-action abilities I have from Culinarian and Alchemist. Culinarian has a +150% but it's only on Rainbow which isn't always guaranteed. With Byregot's blessing and a +125% ability i can sometimes get around 150-300 quality in one action if I get a great Success. I also use Determination + Standard Synth as my first action for the progress boost. Brand of X is really useful and I don't like taking them off especially since elemental overloads are so common on higher level synths.

It's really nice though, there is a lot of open-endedness to how you can approach crafting ability-wise.