I've experienced a lot of ending in Anime and Manga from personal favorites like Sailor Moon, GaoGaiGar Final, and Yu Yu Hakusho to mainstream favorites like Full Metal Alchemist (Both versions), Gundam Wing, Gundam Seed/Seed Destiny, and Dragonball Z.

But the fact that after this next monthly break that One Piece is going into its final saga is a little surreal. With how big it is, I really wonder what they are gonna do when the final chapter drops. They already have rules in place for how they release certain other games and manga. Its gonna be really big.