Enemy mob attacks, especially crits, can interrupt spellcasting. I think that's based on how much you lose on the attack. 15-20% of your max HP on a single strike/action can interrupt casting.
Also, telegraphs can force you to move while having the other mobs stuck on you, otherwise you risk getting interrupted by a unlucky crit.
And then there are status effects. Rare as they are, stun and paralyze can ruin your day.



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