The scene after completing Amaurot where the WoL ends up speaking with a voice... not theirs... very much springs to mind (spoilered for those not up to ShB yet):
WoL (speaking with Ardbert's voice): "This world, is not yours to end... This is our future! Our story!"
(Emet sees the WoL replaced with an Ancient, and reacts with horrified realization)
Emet: "No.. it can't be!"
Lightening up the mood a little (pun intended), I laughed at the top dialogue option when Grenoldt was met for the first time during ShB:
"Has it really come to this?"
I admit I just lost it when I saw that, especially seeing my character's hilarious mock-surrender gesture. :P
(For those who don't get the joke, Grenoldt resembles a certain drunken weaponsmith in Hyrstmill on the Source you get your relic from, even down to having a similar name.
).