Have done a full system reset, underclocked, changed BIOS settings, changed frame rate caps in and out of game, disabled full screen optimizations.. Nothing.
No other program is having any issues, I have tried several other games all running Dx11 and none have brought up any issues. I am leaning towards the problem being something with the current patch of the game, having seen several other forum posts about this topic that usually point at the issue appearing after a recent patch.