I use a combination of methods, depending on how tired and/or lazy I'm feeling.

Normally - WASD and mouse
The more lazy/tired I get - WASD + QE and the arrow keys for turning the camera (generally during fights that don't require any brain cell activity)

For my hotbars, I always double-bind my keys when I'm able to. 1 through = and NumPad 1 through / * - (NumPad 0 when I can't use / ). I'll use a combination of the two throughout any play session.