I have moderate to severe carpal tunnel so I mostly use my mouse for movement/camera. The mouse also controls 7-0 and the other hot bars.
I've taken to wearing a brace on my left wrist when I play but still use it for keys 1-6 `is left strafe and wasd. Tab target pinky and z..thumb controls c(haracter) space(jump) m(ap). When I run I keep my left index on w just in case my other hand let's go of the mouse button.