Regular keyboard + MMO mouse.
I move with QWES and turn my camera with my mouse. Only very rarely I move by holding both mouse buttons because I prefer to be able to simultaneously but independently move my character and turn my camera.
Hotbar is ^12345 because I can't comfortably reach further than that without taking my fingers off the movement keys or doing weird finger gymnastics. Other keybinds are ADRFTGYXCV, mostly for cooldowns. Rest is on mouse buttons and alt + mouse button.
Enough keybinds to hotkey ever single skill + role skill from all classes and some extras like potions.