I’ve only ever played using keyboard and mouse, and even then it’s 90% keyboard.

The biggest thing to do is map your hot bar to both then top numbers and the numpad so either hand can hit skills. From there just make sure to use Ctl and alt to the best you can For hot bar 2 and 3. Also as btw, you can use both Ctrl and alt together for a fourth bar.

For me this set up let’s either hand move me (mouse or wads) and use my skills as needed..especially ogcd skills.