MCH has hypercharge windows where you need to press something like 13 skills in a 10s window. I would definitely not recommend it if you have any issues with your hands.
I would think that you would be better off not handling classes that weave a fair amount or have extra skill speeds. SAM is a pretty forgiving and accessible melee but it might not be good for someone requiring low APM.

Like someone else said, BLM and DRG are probably going to be your best options for DPS when it comes to lesser amounts of strain on the hands.

Macros are not usually good to use with dps skills and tend to be discouraged. With that said, depending on what content you plan on doing it could be adequate for your specific case.