I use legacy settings without the strafes on WASD. Allows me to move only with one hand if I need to, though 99% of the time I'll lock camera view with right click and move with the keyboard. No awkward slow backwards steps pretty straightforward. You can also point your camera an shoot straight which can help with some mechanics (while not having to hold any mouse keys down).
I use simple single action mouseover macros for my healing spells. There's no real harm in doing so and it removes having to switch targets entirely from your "workflow".