4 Expansions later and tab targeting is still bad.

[DumdogsWorld]

Clicking all of your abilities AND your targets with the mouse alone is the most optimal way to play.

Personally, I can't even fathom even attempting to do that, let alone actually playing like that.

But, since this is all a matter of preference anyway, the keyboard is a no-go either IMO.

12 button mouse + modifiers. And it's difficult to run out of hotbars because you can combine modifiers. Got shift, alt, and ctrl already mapped? Use a hotbar for ctrl+shift.