I don't use PopOS but since it seems to be a Linux distribution maybe my experiences from Debian are useful. I'm using Lutris, with wine version lutris-4.21-x86_64 and DXVK. The new launcher interface does not work so I have to use the old one for now (set Browser 1 in ffxiv_boot.cfg). The installer script available from lutris.net seems to do all the right tricks.