I've been having issues as well. Doing synths a mere 2 levels above me, I'll just randomly start failing every single action. Even standard actions on white/yellow. It's rather frustrating, and it really makes me wish crafting was less luck based.

As it is, I use up to date items across the board, including accessories and food, wait on red or flashing (Unless I'm doing good and can afford to do careful for quality, where I want red), and yet still there's the odd occasional synth where things just go horribly, horribly wrong, and I can't see how this is a good thing. I know the combat classes would call bullshit if some marmot their level suddenly started evading like it had popped Perfect Dodge and started critting on every hit.