It didn't seem to matter what I was doing, though I was generally either crafting or going through menus. The issue seems to have stopped. After changing that registry value to 4 (based on advice on a windows10 cold boot freezing issue I read about elsewhere). I actually got a BSOD, and was having occasional slow framerate issues. I changed the value back to 3. And have also had some windows update happen. I haven't had the problem since. So it's all good for now