I suspect it would be possible. It wouldn't be easy by any stretch, though with the Warrior of Darkness being more powerful than ever before and the heavy revelations in regards to the powers of creation I can't discount the Hydaelyn and Zodiark story arc ending with both of them being successfully dealt with on a permanent basis.

I have to wonder if Eden will play into it all somehow as that is the next big source of lore revelations until the MSQ's continue in 5.1.