Quote Originally Posted by NosamKin View Post
All the things you have plugged in are pulling more power than the USB can provide. You need a "wall wort" power supply to plug into your USB hub to give it more power. Standard 1.0 USB only provides 0.5 Amps. Mouse 0.1 A + Keyboard 0.1 A + xbox controller 0.4 A .... you just exceeded what the USB can provide.

I had four USB devices plugged in my PC and it wouldn't boot. I could plug them in after boot when power requirements were less and it would all work. Sounds like you are in a similar situation. Extra power for the USB fixed it.
It only happens when in the game though. If it was a power problem, I would expect to see that through various systems and applications.