My tip would be to reassign your hotbar keybinds to what's comfortable to you. I don't use any combination that involves 6 to = because it's just awkward to do. 1-5 should already give you a good amount of actions given that you'll use LCtrl and LShift. Personally, I also use F1-F8 although I don't use any modifier keys for those. Those are usually my buffs and more frequent ones go to the left. I also rebound Q, E, R, F, G and have LCtrl and/or LShift modifiers for those. Try not to overwrite some useful keys around the WASD area. Some default key combinations are actually useful so check first before overwriting them.

It's best if you find the most comfortable for you. I'll share my own hotbar keybinds and maybe you can work from that.

(from left to right, bottom to top)
Hotbar 1 - 1, 2, 3, 4, 5, G, Q, E, F, R, (unbound), ` (my sprint button)
Hotbar 2 - LCtrl + (1, 2, 3, 4, 5, G, Q, E, F, R), (unbound), (unbound)
Hotbar 3 - LShift+1, LShift+2, LShift+3, LShift+4, LShift+5, LShift+G, LShift+C, LShift+E, Alt+E, LShift+Mouse4, LShift+T
Hotbar 4 - F1, F2, F3, F4, F5, F6, F7, F8, F9, (unbound), (unbound), (unbound)

Hotbar 3 is my weirdest so don't think about it too much. The unbound slots are usually just clickables. You shouldn't have problems sticking your kit in the left side most of the time.