I've clicked all of my skills ever since I started. It's just a lot easier for me than trying to mash buttons on the keyboard or using a controller. I have all of my skill placements in my muscle memory so I hardly ever need to look directly at my hotbars (unless I'm playing astro and I need to see my card actions) and my left hand is completely reserved for character movement. I don't have a fancy mmo mouse either, I just use left click for clicking actions and right click to move the camera lol