I have severe arthritis and Lyme disease. One that often makes prolonged play at the computer painful and the other that gives me very limited energy to work with on top of other fun symptoms I'd rather not get into. I don't have it quite as bad as other people thanks to years of treatment but I do tailor my play and progression around my disabilities. I've had to cancel attempts at progression half way through because my hands just start screaming at me or the fatigue gets so bad I need to go lay down.