For a time, I used a strange hybridization that amounted to "game is in keyboard and mouse mode but controls are all gamepad-based", which I achieved by using enabling cross-hotbar on keyboard and mouse mode as others have said. I primarily did this to make certain placement methods for housing easier. I eventually backed out of it when I realized I don't redecorate my house all that often.

I do have my cooldowns on display with a hotbar, though.