Quote Originally Posted by whiskeybravo View Post
Anything you can do to organize them in a way that doesn't conflict with natural movements, for example I try to not use my main attack actions on Left side of the controller since I you'll be using the left analog stick for movement, which makes it hard to move and attack at the same time.
I've gone through the same thought process, and a good thing to think about for left side/right side of the controller is whether skills are instant-cast or need to charge up. Instant ones are better on the right so they can be used while moving, and charged spells on the left since you have to stand still to cast them anyway.

Also, make sure you turn on the two layers of extended controller hotbars (pressing both buttons and double-tapping) to have access to as many skills as possible.