On the left side of my main bar I have all my often used skills like cures and aoes cures, esuna, etc. 1 is always reserved for regen/lustrate/Essential Dignity. The middle of the bar is used for cure boosts and such like largesse. Right side of the bar is for things like aetherflow, cards and such.

I don't have alt/ctrl set up because instead I bound my F keys to my second row which is where I keep things like benediction, aoe shields like collective unconscious and sacred soil and dps abilities. I cure by clicking on names in the pt list so I don't use my F keys for anything else and it makes it super easy and faster to just move my finger up and click instead of clicking on 2 buttons at once having to move my entire hand.

3rd row are things that are not often used and I only click on like pots, protect, raise, ast stances, lucid dreaming, fairy/egi summon and such.

4th row is a shared bar and where I keep things like limit break, basic hp/mp pots and such that all jobs use.