This is how I have mine set up:

The two macros on the left get replaced if I have a specific one to use for a certain fight, like marking the shell in Susano and such.

Yes, I don't use keybinds at all. I know most people are going to call me out on it but I've gotten so used to the layout that I can weave OGCDs just fine without them. Even double weaving when I need to hasn't been a problem.