I have a set button-pattern for all games like this, be it WoW, FFXIV or countless other MMORPGS.

Numeric Keys, with or without modifiers depending on button-amount (typically for emergency or burst buttons).
QWERTY with and without SHIFT and/or CTRL modifiers (typically for sub-abilities).
ASDFGH with and without SHIFT and/or CTRL modifiers (typically for main-abilities).

It is worth mentioning that should any button (such as SHIFT + W) require pressing whilst moving, games such as WoW/FFXIV etc allow you to run by holding LMB+RMB together, hence there is no detriment to either movement or abilities when bound this way. I very rarely move with WASD other than to strafe, hence I bind SHIFT/CTRL + S/W but not A/D.

Here's some screenshots of my WHM, WAR and BRD buttons for example.
https://imgur.com/3qEVGbJ
https://imgur.com/9ZkGV1O
https://imgur.com/QxYSg9Y

As you can see, it's not dissimilar to how I have my bars setup in WoW:
https://i.imgur.com/qoNROBN.png