Is there anything meaningful/gratifying to do in this game that's not MSQ?

[JohnJacobAstor]

There's a lot to do in this game but at your point you've at least seen or heard of everything, and if none of that holds any appeal for you, your tone already sounds like you're done with the game, and it's probably not for you.

My tone aside, can you tell me concretely what those things are that I can do? Anyone in my position would be frustrated, but I've summed up my predicament as best I could, and legitimately am wondering if there is anything else I can do that has some lasting impact on my character and isn't gated behind endless MSQ that I do for hours everyday despite it boring me to tears.