Can you clear all content as Samurai?
Yes

Will it be harder on Samurai than other classes?
Yes

The reason why it will be harder is because the community does not like Samurai for raids. Anyone who raids on a high level will lock out Samurai in Party Finder. You may ask why?
Now if I get a Samurai who doesn't know what he's doing, he's useless. If i on the other hand get a DRG or Ninja that knows at least how to press Battle Litany, use Trick attack or apply piercing debuff, I get some utility out of them.
Barely anyone on a high level of raiding plays Samurai, which is why the mediocre playerbase follows with the idea of "Samurai is not as good as other classes" when they don't even understand why.

The best example would be the following:
At the release of Zurvan Warrior got locked out of it by 90% of Party Finders. This is due to tacking a supposed stack Mechanic alone with Hallowed Ground. The community sees this, they think warrior is bad and lock it out. At the same time, these people are unable to Skip Soar (Good Meme) as 5 DPS players.
The funny thing is that Warrior was able to take the shared damage with the right cooldowns. It's just how the community works. Top players do something for them because of good reasoning, the mediocre players copy it without even knowing why.

Play Ninja or Dragoon and enjoy the easy party finder life. People will love you.