I'm a pure cross hotbar user because health issues can often put me in a spot where I can't sit up for mouse and keyboard. I'm just going to post my main job's. The top 3 on the right change for my jobs, the rest are universal. I try to put my most vital skills on my top combat hotbar. Since I only play casters I usually switch to the others while I'm casting to go over my options really quick so I can plan my next action once the cast is done. Like while adlo-ing the tank I'll check the monster's cast and like switch to SET 2 and get ready to put down sacred soil for a room ride aoe as soon as the adlo is done. Four is my main food, items, LB, a follow macro that's mostly for maps, a warning macro, SMN/SCH stuff. Left set is like social, travel, and interface stuff.