You can also use the "mouse over" macro : it casts the skill on the target you are pointing with your mouse.
/ac Aetherial Manipulation <mo>
So it's easy to target someone you see outside of an AoE while still adapting to the situation.

(or of course as it has been said you can use a targeted macro directly, but then who to pick, maybe someone you trust in to dodge aoe + someone who is not usually that far from your lines to quickly go back in like a range dps).