I'd suggest taking your first job up the normal way, since the leveling potion will not let you skip the MSQ - there's a separate potion for that (and it will cost you $50 total to skip up to 60 AND be at the start of Stormblood). Also, if you try to do the new stuff introduced in 4.x without any experience that comes with getting to that point, you might draw ire from fellow players who expect you to know how to play.

Some job quests are better than others, but they're all worth doing at least once. Like others have said the skips are better for alt jobs and characters rather than your first time main.