During Shisui of the Violet Tides I lost audio just before the first boss. One other time I lost audio was during a level 50 dungeon, it might have been the Wanderers Palace(Hard) but I'm not certain. Both times I happened to be tanking on PLD or DRK.

After the audio cut out I tabbed out and checked iTunes and a random YouTube video to see if I had audio outside of FFXIV and both times I was still able to hear audio outside of the game. To fix it, I'd have to shutdown the client and open it back up. Maybe just logging out would have helped, but I didn't try that. I restarted the client both times.

Some additional information: I'm always using headphones and they are always plugged into the rear jack that goes straight into my motherboard.

Code:
-=-=-=-=-=-=- FFXIV Information -=-=-=-=-=-=-

MyDocument	Z:\Users\UKGC\Documents
FINAL FANTASY XIV - A Realm Reborn	C:\Program Files (x86)\SquareEnix
FINAL FANTASY XIV - A Realm Reborn	Language 1		Region 3
ProxyEnable 0
ProxyServer unspecified
ProxyOverride *.local


-=-=-=-=-=-=- System Information -=-=-=-=-=-=-

SYSTEM_OS	Windows 10 Home 64-bit (6.2, Build 9200) (16299.rs3_release.170928-1534)
SYSTEM_CPU	Intel(R) Core(TM) i5-4670K CPU @ 3.40GHz (4 CPUs), ~3.4GHz
SYSTEM_CORE_NUM	SYSTEM_CORE_LOGIC 4  SYSTEM_CORE_PHYSICS 4
SYSTEM_BIOS	BIOS Date: 06/26/13 21:19:24 Ver: 12.05
SYSTEM_LANGUAGE	English (Regional Setting: English)
SYSTEM_MEMORY	8130.535MB
SYSTEM_VIRTUAL_MEMORY	134217727.875MB
SYSTEM_PAGE_FILE	8130.535MB
SYSTEM_STORAGE	C:\    SYSTEM_HARDDISK_DRIVE    SYSTEM_TOTALDISC_SPACE 106.535GB    SYSTEM_FREEDISC_SPACE 42.327GB
SYSTEM_STORAGE	Z:\    SYSTEM_HARDDISK_DRIVE    SYSTEM_TOTALDISC_SPACE 465.759GB    SYSTEM_FREEDISC_SPACE 338.049GB
SYSTEM_DIRECTX_VERSION	DirectX 12
SYSTEM_GRAPHICS	NVIDIA GeForce GTX 770
SYSTEM_GRAPHICS_DEVICE	\\.\DISPLAY1
SYSTEM_GRAPHICS_CHIP	GeForce GTX 770
SYSTEM_GRAPHICS_MAKER	NVIDIA
SYSTEM_GRAPHICS_VRAM	2017.688 MB
SYSTEM_GRAPHICS_SHARED_VRAM	4065.268 MB
SYSTEM_GRAPHICS_DAC	Integrated RAMDAC
SYSTEM_GRAPHICS_DISPLAY_MODE	1920 x 1080 (32 bit) (60Hz)
SYSTEM_GRAPHICS_DRIVER	C:\WINDOWS\System32\DriverStore\FileRepository\nv_dispi.inf_amd64_f936d37e592b25aa\nvldumdx.dll,C:\WINDOWS\System32\DriverStore\FileRepository\nv_dispi.inf_amd64_f936d37e592b25aa\nvldumdx.dll,C:\WINDOWS\System32\DriverStore\FileRepository\nv_dispi.inf_amd64_f936d37e592b25aa\nvldumdx.dll,C:\WINDOWS\System32\DriverStore\FileRepository\nv_dispi.inf_amd64_f936d37e592b25aa\nvldumdx.dll
SYSTEM_GRAPHICS_DRIVER_VERSION	23.21.0013.8813
SYSTEM_GRAPHICS_DRIVER_DATE	10/27/2017 00:00:00
SYSTEM_GRAPHICS_DRIVER_LANGUAGE	English
3.0
SYSTEM_GRAPHICS_PIXEL_SHADER	3.0
SYSTEM_GRAPHICS_VERTEX_TEXTURE	SYSTEM_SUPPORT
SYSTEM_SOUND	Speakers (Realtek High Definition Audio)
SYSTEM_SOUND_DEVICE_ID	{8A96D8EB-B423-4A88-909B-2C59D26DB4AF}
SYSTEM_SOUND_DEVICE_NAME	RTKVHD64.sys
SYSTEM_SOUND_DRIVER_VERSION	6.00.0001.7535
SYSTEM_SOUND_DRIVER_LANGUAGE	English
SYSTEM_SOUND_DRIVER_DATE	6/16/2015 00:00:00
SYSTEM_SOUND	SMT24A350-4 (NVIDIA High Definition Audio)
SYSTEM_SOUND_DEVICE_ID	{936947B2-5CBC-4A87-AF17-BF4A0B88694A}
SYSTEM_SOUND_DEVICE_NAME	nvhda64v.sys
SYSTEM_SOUND_DRIVER_VERSION	1.03.0035.0001
SYSTEM_SOUND_DRIVER_LANGUAGE	English
SYSTEM_SOUND_DRIVER_DATE	9/14/2017 00:00:00
SYSTEM_SOUND	Realtek Digital Output(Optical) (Realtek High Definition Audio)
SYSTEM_SOUND_DEVICE_ID	{EDD493B8-DBDC-40DB-8801-1417669BB3F6}
SYSTEM_SOUND_DEVICE_NAME	RTKVHD64.sys
SYSTEM_SOUND_DRIVER_VERSION	6.00.0001.7535
SYSTEM_SOUND_DRIVER_LANGUAGE	English
SYSTEM_SOUND_DRIVER_DATE	6/16/2015 00:00:00
SYSTEM_SOUND	Realtek Digital Output (Realtek High Definition Audio)
SYSTEM_SOUND_DEVICE_ID	{FCF8FD29-3FE3-452B-979A-7B5765613B8D}
SYSTEM_SOUND_DEVICE_NAME	RTKVHD64.sys
SYSTEM_SOUND_DRIVER_VERSION	6.00.0001.7535
SYSTEM_SOUND_DRIVER_LANGUAGE	English
SYSTEM_SOUND_DRIVER_DATE	6/16/2015 00:00:00
SYSTEM_INPUT	{6F1D2B60-D5A0-11CF-BFC7444553540000}
SYSTEM_INPUT_NAME	Mouse
SYSTEM_INPUT_REMARKS	SYSTEM_GAMEPAD_AXIS 3  SYSTEM_GAMEPAD_BUTTON 8  SYSTEM_GAMEPAD_FOV 0
SYSTEM_INPUT	{6F1D2B61-D5A0-11CF-BFC7444553540000}
SYSTEM_INPUT_NAME	Keyboard
SYSTEM_INPUT_REMARKS	SYSTEM_GAMEPAD_AXIS 0  SYSTEM_GAMEPAD_BUTTON 128  SYSTEM_GAMEPAD_FOV 0
SYSTEM_INPUT	{A2FA6730-0AB3-11E3-8002444553540000}
SYSTEM_INPUT_NAME	Gaming Keyboard
SYSTEM_INPUT_REMARKS	SYSTEM_GAMEPAD_AXIS 0  SYSTEM_GAMEPAD_BUTTON 0  SYSTEM_GAMEPAD_FOV 0
SYSTEM_INPUT	{EC13B8E0-89F0-11E5-8002444553540000}
SYSTEM_INPUT_NAME	Gaming Mouse G600
SYSTEM_INPUT_REMARKS	SYSTEM_GAMEPAD_AXIS 0  SYSTEM_GAMEPAD_BUTTON 0  SYSTEM_GAMEPAD_FOV 0
SYSTEM_INPUT	{A2FA6730-0AB3-11E3-8003444553540000}
SYSTEM_INPUT_NAME	Gaming Keyboard
SYSTEM_INPUT_REMARKS	SYSTEM_GAMEPAD_AXIS 0  SYSTEM_GAMEPAD_BUTTON 3  SYSTEM_GAMEPAD_FOV 0
SYSTEM_INPUT	{A2FA6730-0AB3-11E3-8004444553540000}
SYSTEM_INPUT_NAME	Gaming Keyboard
SYSTEM_INPUT_REMARKS	SYSTEM_GAMEPAD_AXIS 0  SYSTEM_GAMEPAD_BUTTON 24  SYSTEM_GAMEPAD_FOV 0


-=-=-=-=-=-=- Application Information -=-=-=-=-=-=-

FINAL FANTASY XIV
Discord
Windows Shell Experience Host


-=-=-=-=-=-=- Install Information -=-=-=-=-=-=-

Adobe Flash Player 28 NPAPI
Google Chrome
FINAL FANTASY XI: Wings of the Goddess
FINAL FANTASY XI: Treasures of Aht Urhgan
FINAL FANTASY XI: Seekers of Adoulin
FINAL FANTASY XI
FINAL FANTASY XI: Rise of the Zilart
PlayOnline Viewer & Tetra Master
FINAL FANTASY XI: Chains of Promathia
Norton Internet Security
Notepad++ (32-bit x86)
NVIDIA Stereoscopic 3D Driver
The Elder Scrolls Online
Microsoft Visual C++ 2013 x86 Minimum Runtime - 12.0.21005
FINAL FANTASY XI: Wings of the Goddess
FINAL FANTASY XI: Treasures of Aht Urhgan
FINAL FANTASY XI: Seekers of Adoulin
Microsoft Visual C++ 2015 Redistributable (x86) - 14.0.24210
Samsung Magician
FINAL FANTASY XIV - A Realm Reborn
FINAL FANTASY XI
ASUS GPU Tweak
Google Update Helper
Intel(R) Management Engine Components
Microsoft Visual C++ 2005 Redistributable
Microsoft Visual C++ 2013 Redistributable (x64) - 12.0.21005
Microsoft Visual C++ 2015 x86 Minimum Runtime - 14.0.24210
Microsoft Visual C++ 2008 Redistributable - x86 9.0.30729.17
FINAL FANTASY XI: Rise of the Zilart
PlayOnline Viewer & Tetra Master
FINAL FANTASY XI: Chains of Promathia
Google Update Helper
Apple Application Support (32-bit)
Apple Software Update
Microsoft Visual C++ 2012 Redistributable (x64) - 11.0.61030
Microsoft Visual C++ 2015 x86 Additional Runtime - 14.0.24210
Microsoft Visual C++ 2010  x86 Redistributable - 10.0.40219
Realtek High Definition Audio Driver
Microsoft Visual C++ 2015 Redistributable (x64) - 14.0.24210
Microsoft Visual C++ 2013 Redistributable (x86) - 12.0.30501
Microsoft Visual C++ 2013 x86 Additional Runtime - 12.0.21005
Microsoft Visual C++ 2008 Redistributable - x86 9.0.21022
Logitech Gaming Software 8.58
Intel(R) Network Connections 18.1.59.0
VLC media player
Vulkan Run Time Libraries 1.0.3.0
Vulkan Run Time Libraries 1.0.61.0
WinRAR 4.20 (64-bit)
Microsoft Visual C++ 2010  x64 Redistributable - 10.0.40219
Microsoft Visual C++ 2012 x64 Additional Runtime - 11.0.61030
iTunes
Intel® Trusted Connect Service Client
VC_CRT_x64
Bonjour
Intel(R) Network Connections 18.1.59.0
Logitech Gaming Software
Microsoft Visual C++ 2008 Redistributable - x64 9.0.30729.17
Microsoft Visual C++ 2013 x64 Additional Runtime - 12.0.21005
Microsoft Visual C++ 2015 x64 Additional Runtime - 14.0.24210
Microsoft Visual C++ 2013 x64 Minimum Runtime - 12.0.21005
Microsoft HEVC Media Extension Installation for Microsoft.HEVCVideoExtension_1.0.2512.0_x64__8wekyb3d8bbwe (x64)
NVIDIA Ansel
NVIDIA 3D Vision Driver 388.13
NVIDIA Control Panel 388.13
NVIDIA Graphics Driver 388.13
NVIDIA GeForce Experience 3.11.0.73
NVIDIA 3D Vision Controller Driver 369.04
NVIDIA PhysX System Software 9.17.0524
NVIDIA Update 31.0.1.0
NVIDIA SHIELD Streaming
NVIDIA HD Audio Driver 1.3.35.1
NVIDIA Install Application
NVIDIA Miracast Virtual Audio 353.62
NVIDIA Backend
NVIDIA Container
NVIDIA TelemetryApi helper for NvContainer
NVIDIA LocalSystem Container
NVIDIA Message Bus for NvContainer
NVIDIA NetworkService Container
NVIDIA Session Container
NVIDIA User Container
NVIDIA Display Container
NVIDIA Display Container LS
NVIDIA Display Watchdog Plugin
NVIDIA Display Session Container
NVIDIA NodeJS
NVIDIA Watchdog Plugin for NvContainer
NVIDIA Telemetry Client
NVIDIA Telemetry Container
NVIDIA Virtual Host Controller
Nvidia Share
NVIDIA ShadowPlay 3.11.0.73
NVIDIA SHIELD Wireless Controller Driver
NVIDIA Update Core
NVIDIA Virtual Audio 4.02.2
Apple Mobile Device Support
Microsoft Visual C++ 2015 x64 Minimum Runtime - 14.0.24210
Microsoft Visual C++ 2012 x64 Minimum Runtime - 11.0.61030
Apple Application Support (64-bit)


-=-=-=-=-=-=- Proccess Information -=-=-=-=-=-=-

C:\Program Files (x86)\Google\Chrome\Application\chrome.exe	00000F78
C:\Program Files (x86)\NVIDIA Corporation\NvContainer\nvcontainer.exe	00002334
C:\Program Files (x86)\NVIDIA Corporation\NvNode\NVIDIA Web Helper.exe	000012AC
C:\Program Files (x86)\SquareEnix\FINAL FANTASY XIV - A Realm Reborn\boot\ffxivsysinfo64.exe	00001F40
C:\Program Files (x86)\SquareEnix\FINAL FANTASY XIV - A Realm Reborn\game\ffxiv_dx11.exe	00002DF4
C:\Program Files\Logitech Gaming Software\LCore.exe	0000225C
C:\Program Files\Realtek\Audio\HDA\RtkNGUI64.exe	00000A5C
C:\Program Files\WindowsApps\Microsoft.SkypeApp_12.10.572.0_x64__kzf8qxf38zg5c\SkypeHost.exe	00001614
C:\Users\UKGC\AppData\Local\Discord\app-0.0.299\Discord.exe	00001D54
C:\Users\UKGC\AppData\Local\Microsoft\OneDrive\OneDrive.exe	00002C34
C:\WINDOWS\Explorer.EXE	00000F08
C:\WINDOWS\system32\DllHost.exe	000024D4
C:\WINDOWS\system32\SettingSyncHost.exe	00000E24
C:\WINDOWS\system32\backgroundTaskHost.exe	00000794
C:\WINDOWS\system32\conhost.exe	00002DCC
C:\Windows\System32\GameBarPresenceWriter.exe	000017D8
C:\Windows\System32\RuntimeBroker.exe	00001B08
C:\Windows\System32\TiltWheelMouse.exe	00002960
C:\Windows\SystemApps\Microsoft.Windows.Cortana_cw5n1h2txyewy\SearchUI.exe	00001574
C:\Windows\SystemApps\ShellExperienceHost_cw5n1h2txyewy\ShellExperienceHost.exe	000021D8
c:\windows\system32\sihost.exe	00002920
c:\windows\system32\svchost.exe	0000045C
c:\windows\system32\taskhostw.exe	0000265C