Personally, potd runs get monotonous quick. Sure, the rooms are procedurally generated, but only within a limited range of variety. I personally prefer to queue for the top 2-3 dungeons I can access and run leves or craft/gather while I wait, depending on my mood.

Spamming floor 51-60 might be safe for PotD, but otherwise, you risk sinking time into a dungeon that gives you nothing if the party wipes once.