Yes.
Sounds from skills, fire, ice, etc do not have the high pitch some of the macro sounds have. Aditionally many skills have sounds that last longer with milder soundwaves.
The other annoying thing is that many people spam their macro sounds and it's constantly that high pitch sound multiple times per sec over and over. Every time I hear it it causes pain in my ears.
It's not my faulth that I was born with bad ears. I'm not deaf, I hear everything fine I just have hypersensitive ears and the eardrums in both my ears are ruptured and that causes quite some pain with those high pitched macro sounds.