I only use one sound effect in one macro (raising with a single ping) but, until they offer the option to mute such macro sounds I will remove it from them. There's no reason WHATSOEVER I should do something in game that I know may negatively affect someone. I wouldn't do it in the real world, so why in game?

I do get affected by multiple macro sounds myself because they irritate me, which can lead to exacerbation of non-related health issues. So even though I don't have the same problem as the original poster it would be beneficial to me too if they implemented a "macro sounds" slider. They did it for Performance sounds quickly enough (thank the Twelve) so it's obviously not a game-breaking thing to do.