I agree with this post mainly bar the TBN on auto attacks. In all savage raids and shinryu, you can mitigate auto attacks with TBN with a full tenacity set at max ilvl. The timing is to pop TBN as soon as you take an auto attack and it should break providing you don't have another mitigation CD active or have grit activated and providing the boss will use 2 more auto attacks.

Even if you choose to use TBN like this you will still suffer a total DPS loss for the encounter. I do find that using TBN like this (especially in Shinryu) allows DRKS defense to be incredibly powerful.