This is my preference for my WHM hotbar. For this, I have somewhat smaller hands, and I use a trackpad for a mouse.
https://twitter.com/CryBloodwing/sta...16383040364544
I have 3 horizontal bars and one vertical. For the vertical one, I put non combat abilities, like mounts, emotes, teleport, return, dig, etc.
On Row 3(top row) I put the spells that have long cool-downs, are not used much or have a relation to the one below. For example, the three in the first column, from top to bottom are Assize, Holy, Stone. These are my main three DPS abilities. Stone is the most used, so I have assigned that to a number key. The two above have longer cooldowns so I am able to take a few seconds to click them with my mouse.
Next on the bottom row, I put Cure 1 and Cure 2. Both are used very often and 2 and 3 are very easy numbers to press when using WASD to move.
I alway put Swiftcast next to Rez/Raise since this combo is pretty important.
In general, I put most used skills and combos on bottom row. Middle row is less used. Top row is long cooldowns. Going left to right, the skills on the far right are used way less than the others. So the bottom left is most used skills. Top right is skills I almost never use, or stay active until used again(like stances, summoning, etc). Column spells that are similar or have same effects. Most used on bottom, less used on top.