It's not uncommon to get a status ailment like poison or paralysis, the kind that can be cleansed with any of the cleansing abilities (Esuna, The Warden's Paean, Erase if it's poison), but that laughs in the face of my Antidote or Spine Drops.

I understand not being able to cleanse every single status ailment in the game, nor do we have the tools in our disposal to do that only with items. But if it's poison you can cleanse, why doesn't my antidote work?

This has ever been relevant for solo content, but now it's also relevant in group content as your healer might not have crossed Esuna.