I'd love the setting to turn the default to "yes".

I play with keyboard and mouse, and I have bound my confirm to F. Too many times I've 'missed' the tiny "OK/yes" box with a quick mouse move, and if I've hit it, occasionally it doesn't register at all because I click it and then mouse is still on the move and goes past before I have lifted my finger off of the mouse button so I miss it anyway. It's frustrating and overall time consuming when I have to click that confirm in about everywhere I go in-game. (In dungeons it defaults to "yes"...)

What comes to the cursor moved with arrow keys would mean I have to lift my hand off of mouse, look at my keyboard because I definitely can't find those buttons without looking, and then 'return' to actual game-play. That doesn't sound convenient when it comes to playing a game.