Sound imput issues/ How to change sound input wihtout closing the game completely?

[Moonlite]

I have been playing for two years and this hasn't happened to me even once.

My pc is hooked up to 3 different sets of speakers. I do have it set to a default, but because of the way the stereo receiver registers it can actually generate a new location (don't know why). But if i start the game and change to VSX-C from VSX-B the game will crash 100% of the time.