TLDR: Use whatever you are most comfortable with, mouse and keyboard's advantages are nothing like as significant as something like motion controls in Splatoon 2 or mouse and keys in an FPS.
Personally, I couldn't stomach raiding savage etc on a gamepad though. Mouse and keys is rather akin to a somewhat significant ping advantage, I can target party members nigh instantly, turn my camera faster, start moving quicker, stutter step/cast crisper and perhaps most significantly, I'm able to comfortably use all my hotkeys as normal whilst still having complete control over both my motion and camera at the same time.
https://youtu.be/BLGUMzl2cV0?t=7m31s
Is a fairly decent example of this in action. The jumps whilst casting instants allows me to keep moving in a direction whilst using abilities that would otherwise turn me around whilst the ability to manually control where I'm facing via right click whilst moving independently is proving it's weight in gold this tier, what with all of the face away to dodge mechanics we're getting this time round.
It's not going to make or break anyone's level of play, but it is an undeniable advantage once you get it down.