I use a keyboard for chat only, though I do have a horizontal hotbar to track CDs. I have a main out of combat hotbar, then a main combat crossbar plus the expanded secondary crossbar. I use the WXHB as SCH for HW for awhile, but to be honest, I hate it - it's way too easy for me to accidentally activate it, yet have trouble activating it on purpose (if you use an expanded bar, release to normal bar, then go back to expanded, it can activate the W bar without a double tap, even if you do it slowly).

I raid savage (not world first progression) without trouble. Only SCH is a pain due to so many buttons.. I had to move a few skills to a fourth bar that I access manually.