I guess I'm getting old but my left wrist gets uncomfortable after a few instances of mashing buttons.
Are you using a gaming mouse? I personally use a Logitech G600, it has a ton of extra buttons so I don't have to use my left hand for abilities at all, I just use it for movement. I've never been good with controllers, I rarely played console games so I haven't even tried it in this, but with so many abilities now I'm not even sure how it works on a controller with so few buttons.