I keep mine split based on skills I use regularly and Utility. I have a gaming mouse, so the Num Keys on the side are assigned to that, DPS is so simple for AST I didn't need to set keys I could quickly reach.

Cards were where I got to have fun, I keep my primary card skills around WASD, so I can shuffle my cards around while moving, since it's not like I can heal and move, and with the addition of Sleeve Draw and Minor Arcana, I just expanded it a little, Minor Arcana is my least used skill since there's no real need for it at this point unless I draw a bad Spire. Time Dilation and Lucid Dreaming get the same deal with being close to WASD, cause those are oGCD.