Other way around: legacy movement makes it so the direction you press is the direction you go on the screen, while the default movement setting make it so your movement will be based on which direction your character is facing. In Legacy, you will only backpedal if you move back while using the Strafe keys; for this reason, in legacy mode you should unbind "Strafe Left"/"Strafe Right" and use "Move Left"/"Move Right" instead.
In re: mouseovers, character models move a lot, and aren't great targets for mouseovers because they might move, or someone else might move on top of your intended target. You can avoid a lot of mistargeting by mousing over the stationary hud elements instead.