1-5 are the basic actions, I dash in and out with the two side buttons on my mouse, and flare/holy are shift side buttons. Alt+1 for impact, F1-4 for cooldowns/seldom used spells. Alt 2-4 are my supportive abilities. Middle mouse click and shift middle mouse click for aoe. R F V is my melee combo, I started using these due to ninjutsu. I like putting my cooldowns on Shift buttons and Q, so shift Q W E A and Q.

Main takeaway is that you only hit melee skills every 40 seconds or so, but you want them to flow easily. Cooldowns can go anywhere really, but I like to keep them on an upper bar so I can track their status easily. I made a bar above my class gauge to track impact and ready procs if my eyes are watching the fight, and so I can find my "ready" status at multiple locations.